Yes.  The SPYRUS Windows To Go boot drives (WTG) work on many Mac models, particularly those built in 2012 and newer.  To use a SPYRUS WTG on a Mac, you should be running the WTG with a Windows 10 or Windows 8.1 image; Windows 10 is preferred.  The main dependency is the Mac model’s ability to support Boot Camp for the Windows OS version.  The supported Models are available via the following links: Windows 10, Windows 8.0.